6 edition of Molecular Aspects of Anticancer Drug DNA Interaction (Topics on Molecular and Structural Biology) found in the catalog.
August 16, 1993
Written in English
|Contributions||Michael J. Waring (Editor)|
|The Physical Object|
|Number of Pages||1|
A complementary structural and dynamical information on drug-DNA interplay has been achieved at a molecular level, for Pt/Pd-drugs, allowing a better understanding of their pharmacodynamic profile. The interaction of two cisplatin-like dinuclear Pt(II) and Pd(II) complexes with DNA was studied through a multidisciplinary experimental approach, using quasi-elastic neutron . The molecular basis for designing DNA binding drugs with improved specificity and affinity stems from the ability to identify the structural elements of the drug that are responsible for the.
Molecular dynamics simulation and free energy analysis of the interaction of platinum-based anti-cancer drugs with DNA. Journal of Theoretical and Computational Chemistry , 15 (06), DOI: /S III. Unifying structural concepts in understanding drug-DNA interactions and their broader implications in understanding protein-DNA interactions. J Mol Biol. Aug 15; (3)– Waring M. Variation of the supercoils in closed circular DNA by binding of antibiotics and drugs: evidence for molecular models involving intercalation.
Title:Synthesis, Anticancer Evaluation and Synergistic Effects with cisplatin of Novel Palladium Complexes: DNA, BSA Interactions and Molecular Docking Study VOLUME: 16 ISSUE: 1 Author(s):Nenad Joksimović, Nenad Janković, Jelena Petronijević, Dejan Baskić, Suzana Popovic, Danijela Todorović, Milan Zarić, Olivera Klisurić, Milan Vraneš, Aleksandar Tot and Zorica Bugarčić*. Drug-DNA interaction studies are of great significance as it helps in the development of new therapeutic drugs. It provides a deeper understanding into the mechanism through which therapeutic.
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Molecular Aspects of Anticancer Drug DNA Interaction (TOPICS ON MOLECULAR AND STRUCTURAL BIOLOGY) (Vol 1) by Neidle (Author) ISBN ISBN Why is ISBN important.
ISBN. This bar-code number lets you verify that you're getting exactly the right version or edition of a book. The digit and digit formats both work. Molecular Aspects of Anticancer Drug - DNA Interactions aims to be a definitive work in the cancer chemotherapy area replacing the editors previous book on anti-cancer drug design which though still widely quoted as the standard book in the field has now become rather out of date.
Molecular Aspects of Anticancer Drug DNA Interactions, Vol. 2: Topics in Molecular and Structural Biology: Medicine & Health Science Books @ Selectivity in Alkylating Agent-DNA Interactions. Structure-Activity Studies of Anthracycline-DNA Complexes.
Advances in the Study of Pyrrolo[2,1-c][1,4] Benzodiazepine (PBD) Antitumour Antibiotics. Molecular Aspects of the Interaction of (+)-CC with DNA. Molecular Aspects of Platinum-DNA Interactions. New Platinum Drugs. Molecular Aspects of Anticancer Drug - DNA Interactions ; A definitive work in the cancer chemotherapy area, this second volume continues the work of the first in providing an up-to-date publication presenting the research of the most prominent workers in the field.
Volume one was also published in Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (K), or click on a page image below to browse page by : M.
Feely. Main Molecular Aspects of Anticancer Drug-DNA Interactions: Volume 2 Due to the technical work on the site downloading books (as well as file conversion and sending books to email/kindle) may be unstable from May, 27 to May, 28 Also, for users who have an.
The finding of the direct binding of quinolone to DNA has triggered more detailed investigations on the role of drug–DNA interaction in the enzyme inhibition. The binding of [3 H]norfloxacin to supercoiled ColEl DNA (as illustrated in Fig. 3) demonstrates a specific type of drug binding based on the following observations: (1) the binding is saturable and takes place at the drug's.
Molecular docking and QSAR studies were carried out for the investigation of interactions between 11 antitumor drugs and double stranded DNA. Quantitative structure activity relationship was established using MOE software package showing good correlation of binding strength with various physicochemical parameters e.g., hydrophobic surface area (V surf), E HOMO, E HUMO.
Molecular Aspects of Anti-Cancer Drug Action | Stephen Neidle, Michael J. Waring (eds.) | download | B–OK. Download books for free. Find books. Explore the latest full-text research PDFs, articles, conference papers, preprints and more on DRUG-DNA INTERACTION. Find methods information, sources, references or conduct a literature review on.
Docking interaction of 2- 4-substituted and 2,4-disubstituted 1-hydroxyanthraquinones indicates intercalative mode of binding of compounds with DNA topoisomerase. The interaction with the DNA of 4-aryl- 13, 15, 16 and 4-(furanyl)- 23 1-hydroxyanthraquinones was experimentally confirmed through a change in electroforetic mobility.
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Molecular Aspects of Anticancer Drug DNA Interactions (Topics in Molecular and Structural Biology) 作者: Stephen Neidle 出版社: CRC 出版年: 定价: USD 装帧:. Classifications of DNA binding molecules - Drug interactions 8.
Structures of quadruplex nucleic acids and their drug complexes 9. Solvent-accessible surfaces of proteins and nucleic acids Nucleic acid medicines as green novel anticancer drugs Correlation between nucleic acids and nanoparticle therapeutics for cancer treatment Here in a single source is a complete spectrum of ideas on the development of new anticancer drugs.
Containing concise reviews of multidisciplinary fields of research, this book offers a wealth of ideas on current and future molecular targets for drug design, including signal transduction, the cell division cycle, and programmed cell death. Molecular Aspects of Anticancer Drug DNA Interactions Book Summary: This cutting-edge book surveys the current knowledge on the mode of action of the major classes of DNA-interactive antitumor agents, providing information that could be crucial for the discovery of new therapeutic substances.
It is an important reference for molecular biologists, cancer researchers, biochemists, biophysicists. Molecular aspects of anticancer drugs-DNA interactions. Volume 1. Molecular aspects of anticancer drugs-DNA interactions. Volume 1. Lennard L. British Journal of Clinical Pharmacology, 01 Jan37(1): PMCID: PMC.
The development of anticancer drugs started over four decades ago, with the serendipitous discovery of the antitumor activity of cisplatin and its successful use in the treatment of various cancer types.
Despite the efforts made in unraveling the mechanism of the action of cisplatin, as well as in the rational desi. Complementary structural and dynamical information on drug–DNA interplay has been achieved at a molecular level, for Pt/Pd-drugs, allowing a better understanding of their pharmacodynamic profile which is crucial for the development of improved chemotherapeutic agents.
The interaction of two cisplatin-like di PCCP HOT Articles. Molecular simulations provide an atomic-level understanding of the molecular mechanisms of metallo-drugs, and can be further employed for their rational design.
Conventionally, metallo-drugs are believed to target mostly canonical B-DNA; as such, most of the literature studies focus on their binding to short DNA oligonucleotides (naked DNA).Cancer is a multifactorial family of diseases that is still a leading cause of death worldwide.
More than different types of cancer affecting over 60 human organs are known. Chemotherapy plays a central role for treating cancer. The development of new anticancer drugs or new uses for existing drugs is an exciting and increasing research area.
This is particularly important since drug.the norfloxacin - DNA complex formation was estimated to M Previously, we have investigated the interaction of ciprofloxacin with ds-DNA by 1H NMR and molecular docking calculations. Ciprofloxacin was found to interact both in the minor and major groove as evident from NOESY cross-peaks and chemical shifts.